Introduction: Despite the popularity of NEEDLE BIOPSY for obtaining tissue samples in several solid organs, its use in thoracic lesions has been very restricted in some hospitals. This study intended to investigate the CT-Guided TRANSTHORACIC core NEEDLE BIOPSY specimens in Yazd Shahid Sadoughi hospital during 2001- 2010.Methods: This is a retrospective cross- sectional study conducted on pathologic results of CT-Guided TRANSTHORACIC core NEEDLE BIOPSY specimens in Shahid Sadoughi hospital from 2001-2010.Results: In our study, 89 thoracic CNB were studied between2001-2010 from patients that referred to Sadoughi hospital who involved 53 males and 36 females. 78 biopsies were from lung and 11 biopsies from Mediastin. In a total of 89 biopsies 71 biopsies (78.9%) supplied appropriate material for histopathological diagnosis. Results were classified into one of the following four groups: positive or suspicious for malignancy (19.1%), benign specific (34.8%), benign non-specific (25.8%) and non-diagnostic (20.2%).Conclusion: Based on multivariate analysis there was no significant correlation between age, sex, size of lesion and pathology results, but there was a significant correlation between the location of thoracic lesion in lung and pathology results (p-value=0.024). Application of automated system for BIOPSY and fluoroscopy CT for guidance of NEEDLE BIOPSY can elevate adequacy of core NEEDLE BIOPSY in thoracic lesion.

Background and Aim: Fine NEEDLE Aspiration BIOPSY is an effective diagnostic method in the field of medical pathologies. Easiness, accuracy, validity and usefulness of this method have been verified frequently. This method is useful not only for soft tisse or even intraosseous lesions, but also recurrence of tumors (metastasis), resistence to treatment, verification of malignancy, differentiation between malignancy and benignment and determination of organisms causes infection. Unfortunately the use of this method is not common in dental pathology. So this study intendes to show the diagnostic value of FNA specially for intraosseous lesions causing jaw radiolucency.Methods and Materials: This investigation consisted of 80 patients who were referred to Taleghani General Hospital who were then referred to the pathology or surgery departments at Shahid Beheshti dental school.Cases consist of 29 females (36.25) % and 51 males (63.75%). Sampletaking was conducted using a 10 cc, gauge 19 syringe.Results: Results show 90% sensitivity and 75% specificity for jaw radiolucent lesions in FNA method. Correlation between FNA and jaw radiolucencies was significant (P<0.001) and it's power was at equal accepctable level according to cramer's V (phi - cramer's =0.623). Based on FNA cytology power, lesions with positive predictive value of 78.30 had a microscopic view compatible to the findings of other similar studies.Conclusion: FNA can be used as a reliable method for rapid, early and in expensive diagnosis, resulting in an on time, and appropriate treatment plan.